Sancar, “heyecan verici ke\u015fif” olarak tan\u0131mlad\u0131\u011f\u0131 \u00e7al\u0131\u015fmas\u0131na ili\u015fkin ilk a\u00e7\u0131klamay\u0131, 17 \u015eubat 2022’de yapt\u0131. Aradan ge\u00e7en s\u00fcrede laboratuvar\u0131nda geni\u015f kapsaml\u0131 \u00e7al\u0131\u015fmalar yapan ve fareler \u00fczerindeki deneylerini s\u00fcrd\u00fcren Sancar, geldi\u011fi bilimsel a\u015famaya ili\u015fkin AA muhabirinin sorular\u0131n\u0131 yan\u0131tlad\u0131.<\/p>\n\n\n\n
Nobel \u00d6d\u00fcl\u00fc verilen “h\u00fccrelerin hasarl\u0131 DNA’y\u0131 tamir ederek genetik bilgiyi nas\u0131l koruduklar\u0131n\u0131 molek\u00fcler d\u00fczeyde haritalayan” konu \u00fczerine 10 y\u0131l \u00e7al\u0131\u015ft\u0131\u011f\u0131n\u0131 dile getiren Sancar, bu bilgi birikimiyle farkl\u0131 alanlarda da ara\u015ft\u0131rmalar\u0131n\u0131 s\u00fcrd\u00fcrd\u00fc\u011f\u00fcn\u00fc anlatt\u0131.<\/p>\n\n\n\n
Molek\u00fcler biyolojide en fazla kullan\u0131lan kimyasal maddelerden birinin EdU molek\u00fcl\u00fc oldu\u011funu aktaran Sancar, h\u00fccre k\u00fclt\u00fcr\u00fcne konulan EdU’nun hem normal h\u00fccreleri hem de kanser h\u00fccrelerini \u00f6ld\u00fcrd\u00fc\u011f\u00fcn\u00fcn birka\u00e7 y\u0131l \u00f6nce bilim insanlar\u0131nca bulundu\u011funu ancak \u00e7al\u0131\u015fmalar\u0131n ilerletilemedi\u011fini dile getirdi.<\/p>\n\n\n\n
Beyin t\u00fcm\u00f6rlerinin, \u00f6l\u00fcm nedenleri aras\u0131nda 10’uncu s\u0131rada yer ald\u0131\u011f\u0131n\u0131 belirten Sancar, “kan-beyin” bariyerini ge\u00e7emeyen mevcut kanser ila\u00e7lar\u0131n\u0131n bu kanser t\u00fcr\u00fcne etki etmede yetersiz kald\u0131\u011f\u0131n\u0131 s\u00f6yledi.<\/p>\n\n\n\n
Kanserli hastalar\u0131n b\u00fcy\u00fck \u00e7o\u011funlu\u011funda kullan\u0131lan “Cisplatin” adl\u0131 ilac\u0131n bu bariyerden ge\u00e7emedi\u011fini ifade eden Sancar, EdU molek\u00fcl\u00fcn\u00fcn ise sorun olmadan beyne girebildi\u011fini belirterek, “Ke\u015ffimizde, ortaya koydu\u011fumuz bile\u015fen, beyne kolayl\u0131kla giriyor ve kanser h\u00fccresini \u00f6ld\u00fcr\u00fcyor.” dedi.<\/p>\n\n\n\n
Laboratuvar deneylerinin ard\u0131ndan fare deneylerine ba\u015flad\u0131klar\u0131 bilgisini veren Sancar, bu s\u00fcreci \u015f\u00f6yle anlatt\u0131:<\/p>\n\n\n\n
“\u00dcniversitelerdeki sinirbilim b\u00f6l\u00fcmleriyle g\u00f6r\u00fc\u015ferek insan beyin t\u00fcm\u00f6r par\u00e7as\u0131n\u0131 al\u0131p fare beyni dilimleri \u00fczerine koyarak ger\u00e7ekli\u011fe benzeyen h\u00fccre boyu olu\u015fturuldu. Fare beynine insan t\u00fcm\u00f6r h\u00fccreleri enjekte edildi ve EdU’nun beyin t\u00fcm\u00f6rlerine etkisine bakt\u0131k. Farelerde, ilk etapta mevcut ila\u00e7 daha iyi etki g\u00f6sterirken, 30-40 g\u00fcn sonra EdU molek\u00fcl\u00fcn\u00fcn daha iyi etki etti\u011fini, bunun y\u00fczde 25’lere ula\u015ft\u0131\u011f\u0131n\u0131 g\u00f6rd\u00fck. Mevcut ila\u00e7larla kombine edildi\u011finde ise sonu\u00e7lar daha iyi geldi.”<\/p>\n\n\n\n
Toksisitesi ve h\u0131zl\u0131 b\u00f6l\u00fcnen h\u00fccrelere y\u00f6nelik se\u00e7icili\u011fi g\u00f6z \u00f6n\u00fcne al\u0131nd\u0131\u011f\u0131nda, EdU’nun kanser tedavisinde kullanma olas\u0131l\u0131\u011f\u0131n\u0131n ortaya \u00e7\u0131kt\u0131\u011f\u0131n\u0131 bildiren Sancar, \u015funlar\u0131 kaydetti:<\/p>\n\n\n\n
“EdU’nun \u00f6zellikleri, onu etkili bir beyin kanseri ilac\u0131n\u0131n temeli haline getirebilir. EdU, h\u0131zl\u0131 b\u00f6l\u00fcnen kanserli beyin h\u00fccrelerini \u00f6ld\u00fcrebilirken, b\u00f6l\u00fcnmeyen sa\u011fl\u0131kl\u0131 beyin h\u00fccrelerini koruyabilir. Beyin kanserinde EdU, hayvanlarda \u00e7al\u0131\u015f\u0131yor, insanlarda kullan\u0131labilmesi i\u00e7in iki y\u0131l boyunca klinik deneylerde yan etkilerini ara\u015ft\u0131rmam\u0131z gerekiyor. Bu s\u00fcre boyunca EdU molek\u00fcl\u00fcn\u00fcn insanlardaki yan etkisine odaklanmam\u0131z gerekecek. DNA onar\u0131m\u0131yla ilgili bu yeni metodu, T\u00fcrkiye’ye de aktarmak i\u00e7in de \u00e7abal\u0131yorum.”(AA)<\/p>\n","protected":false},"excerpt":{"rendered":"
Sancar, “heyecan verici ke\u015fif” olarak tan\u0131mlad\u0131\u011f\u0131 \u00e7al\u0131\u015fmas\u0131na ili\u015fkin ilk a\u00e7\u0131klamay\u0131, 17 \u015eubat 2022’de yapt\u0131. Aradan ge\u00e7en s\u00fcrede laboratuvar\u0131nda geni\u015f kapsaml\u0131 \u00e7al\u0131\u015fmalar yapan ve fareler \u00fczerindeki deneylerini s\u00fcrd\u00fcren Sancar, geldi\u011fi bilimsel a\u015famaya ili\u015fkin AA muhabirinin sorular\u0131n\u0131 yan\u0131tlad\u0131. Nobel \u00d6d\u00fcl\u00fc verilen “h\u00fccrelerin hasarl\u0131 DNA’y\u0131 tamir ederek genetik bilgiyi nas\u0131l koruduklar\u0131n\u0131 molek\u00fcler d\u00fczeyde haritalayan” konu \u00fczerine 10 y\u0131l …<\/p>\n